How immy Works: The Science of Mycolicibacterium aurum Aogashima

For decades, the immune system has been studied through the lens of pathogens—bacteria and viruses that cause disease. However, emerging research has revealed a deeper, more intricate relationship between the human immune system and the microbial world. Not all bacteria are harmful; in fact, some are essential for maintaining immune balance. 

Today, due to urbanization, excessive hygiene, and reduced microbial diversity in modern diets, our immune systems lack these critical microbial interactions, contributing to a rise in inflammatory disorders, autoimmune diseases, and stress-related conditions.

Among these, environmental mycobacteria such as Mycolicibacterium aurum Aogashima (the active ingredient in immy) and its close relative Mycolicibacterium vaccae have demonstrated profound potential effects on immune regulation, inflammation control, and stress resilience.

These bacteria are part of an ancient group known as the Mycobacteriaceae family, which includes both pathogenic and beneficial species. While harmful mycobacteria like Mycobacterium tuberculosis cause devastating diseases, non-pathogenic strains like M. vaccae and M. aurum have evolved in a symbiotic relationship with humans, training the immune system to respond appropriately to threats without overreacting.

Harnessing the Power of Environmental Mycobacteria

The benefits of M. vaccae were first discovered by accident. In the 1970s, scientists researching tuberculosis (TB) vaccines in Africa made a surprising observation in a rural village. The cattle farmers in the village exhibited significantly stronger immune responses and lower levels of inflammatory disease compared to their counterparts, the cereal farmers, who lived in the same environment but worked primarily in crop fields.

Upon further investigation, researchers discovered that the cattle farmers were regularly exposed to mycobacteria in the mud and soil their cattle walked through. When a TB vaccine trial was conducted in the village, the results were striking—those exposed to mycobacteria through soil demonstrated stronger immune responses, greater vaccine efficacy, and fewer instances of TB infection.

This led researchers to reclassify non-pathogenic mycobacteria as mycolicibacteria, and opened the door to billions of dollars of medical research that eventually led to Dr Akle’s innovation - immy. 

Regulating the Immune System Through T-Cell Modulation

A major reason chronic inflammation persists in the body is the overactivation of pro-inflammatory pathways and the failure of mechanisms that are supposed to counteract them.

Mycolicibacteria like immy work by interacting with the gut lining, where they:

• Support serotonin production by reducing inflammation in the gut, promoting mood stability, cognitive clarity, and stress resilience.

• Reduce autoimmune risk, lower systemic inflammation, and prevent unnecessary immune activation.

By leveraging T-cell regulatory pathways, immy helps restore immune balance, reducing unnecessary inflammation without suppressing the body’s ability to fight infections.

The Gut-Brain Axis: How immy Supports Mood, Stress Resilience, and Cognitive Function

The gut-brain axis is a bidirectional communication system linking the central nervous system (CNS) and the gut microbiome. This pathway is responsible for regulating mood, cognitive function, and stress responses, largely through the production of neurotransmitters and immune signals.

Chronic stress disrupts the gut-brain axis, leading to severe microbial imbalance, increased gut permeability (leaky gut), and heightened inflammatory responses. These conditions ultimately disrupt serotonin production, leading to mental health disorders, cognitive decline, and increased susceptibility to inflammatory diseases.

One of the most compelling findings in M. vaccae research is its ability to modulate neurotransmitter activity, particularly serotonin, which is:

• Essential for mood regulation, stress resilience, and emotional well-being. 

• Almost exclusively produced in the gut, making gut health a key factor in mental stability.

• Reduction of neuroinflammation. 

Importantly, mycolicibacteria like immy have been shown to increase serotonin expression in a region of the brain involved in mood regulation.

These effects explain why individuals using immy often report improved mood, increased focus, and reduced mental fatigue, particularly in high-stress environments.

Restoring the Gut Barrier and Preventing Inflammatory Damage

One of the primary locations where immy exerts its effects is in the gut, particularly in the last 18 inches of the small intestine, where immune cells interact directly with gut bacteria.

Chronic inflammation weakens the intestinal barrier, allowing harmful substances such as bacterial endotoxins and undigested food particles to enter the bloodstream—a phenomenon known as leaky gut syndrome. This process:

• Triggers systemic inflammation as the immune system reacts to foreign invaders

• Exacerbates autoimmune responses, leading to conditions like rheumatoid arthritis and inflammatory bowel disease

• Increases neurological inflammation, contributing to brain fog and cognitive dysfunction

immy may help restore gut integrity by:

• Reducing intestinal inflammation, allowing the gut lining to heal

• Modulating microbiota composition, promoting the growth of beneficial bacteria

• Preventing harmful bacterial translocation, reducing systemic inflammation and autoimmune activation

These gut-stabilizing effects may help explain why many people taking immy experience improvements in digestion, reduced bloating, and overall gastrointestinal health. 

The Long-Term Benefits of Daily immy Use

Unlike probiotics, immy does not colonize the gut permanently, meaning it must be taken daily to maintain its effects.

• The immune system is constantly adapting, requiring consistent microbial training to remain balanced

• The body naturally excretes environmental mycobacteria, meaning their effects are temporary unless replenished regularly

This is why regular use of immy provides sustained immune support, stress resilience, and inflammation control.

For those struggling with chronic inflammation, autoimmune conditions, stress-related disorders, or cognitive decline, immy offers a scientifically backed, natural intervention that may help restore balance where the modern world has disrupted it.

By integrating cutting-edge research on environmental mycobacteria, immune modulation, and the gut-brain connection, immy provides a unique, effective, and scientifically validated approach to supporting long-term immune health.

The information provided here is for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. This does not replace advice from a physician or medical professional. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.